※下線、現及び旧所属者

Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R , Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato XD, Inoue UY, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Elife  2024 Mar 26;12:RP89376

Temma Y, Obi-Nagata K, Hoshiba Y, Miyake R , Katayama Y, Hagihara H, Suzuki N, Miyakawa T, Nakayama KI, Hayashi-Takagi A (CA).
Effect of brain acidification on depression-related behaviors in diabetes mellitus.
Front. Psychiatry  2023 14:1277097.

Obi-Nagata K, Suzuki N, Miyake R , MacDonald ML, Fish KN, Ozawa K, Nagahama K, Okimura T, Tanaka S, Kano M, Fukazawa Y, Sweet RA, Hayashi-Takagi A (CA).
Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.
Sci. Adv. 2023 Jun 9;9(23):eade5973.

Hayashi-Takagi A (CA).
To fire or not to fire: decisions mediated by localized processing and dendritic spikes. 
Nat Rev Neurosci. 2023 Feb.

Hayashi-Takagi A (CA).
Constructive understanding of multi-scale dynamism of psychiatric disorders.
Neurosci Res. 2022 Feb;175:1-2.

Jo SH, Inoue T, Hayashi-Takagi A (CA).
Multi-Scale Understanding of NMDA Receptor Function in Schizophrenia.
Biomolecules 2020;10:1172.

Tsutsumi S (CA), Hayashi-Takagi A (CA).
Optical interrogation of multi-scale neuronal plasticity underlying behavioral learning.
Curr Opin Neurobiol 2020;67:8-15.

Kawamura A, Katayama Y, Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI.
Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.
Hum Mol Genet 2020;29(8):1274-1291.

Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I, Yanai N, Kimizuka N.
Near-Infrared Optogenetic Genome Engineering Based on Photon-Upconversion Hydrogels.
Angew Chem Int Ed Engl 2019;58(49):17827-17833

Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Fujita Y, Tan Y, Hisano Y, Shimamoto-Mitsuyama C, Nozaki Y, Esaki K, Nagaoka A, Matsumoto J, Hino M, Mataga N, Hayashi-Takagi A, Kenji Hashimoto K, Kunii Y, Kakita A, Yabe H, Takeo Yoshikawa.
Investigation of betaine as a novel psychotherapeutic for schizophrenia.
EBioMedicine 2019;45:432-446.

Obi-Nagata K, Temma Y, Hayashi-Takagi A (CA).
Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model.
Proc Jpn Acad Ser B Phys Biol Sci 2019;95(5):179-197.

Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Rep 2018;24(8):2196-2210.e9.

Okazaki H, Hayashi-Takagi A, Nagaoka A, Negishi M, Ucar H, Yagishita S, Ishii K, Toyoizumi T, Fox K, Kasai H.
Calcineurin knockout mice show a selective loss of small spines.
Neurosci Lett 2018;671:99-102.

Zhang JC, Yao W, Qu Y, Nakamura M, Dong C, Yang C, Ren Q, Ma M, Han M, Shirayama Y, Hayashi-Takagi A, Hashimoto K.
Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype.
Sci Rep 2017;7:7133.

Hoshiba Y, Wada T, Hayashi-Takagi A (CA)
Synaptic ensemble underling the selection and consolidation of neuronal circuits during learning.
Frontiers in Neural Circuits 2017; 11, 12.

Shirai F, Hayashi-Takagi A (CA)
Optogenetics: Applications in psychiatric research.
Psychiatry and Clinical Neurosciences 2017;71:636-372.

Hayashi-Takagi A (CA)
Synapse pathology and translational applications for schizophrenia.
Neurosci Res 2017; 114, 3-8.

Miyazaki J, Iida T, Tanaka S, Hayashi-Takagi A, Kasai H, Okabe S, Kobayashi T.
Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy.
Biomed Opt Express 2016; 7, 1702-1710.

Nagaoka A, Takehara H, Hayashi-Takagi A, Noguchi J, Ishii K, Shirai F, Yagishita S, Akagi T, Ichiki T, Kasai H.
Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo.
Sci Rep 2016; 6, 26651.

Hayashi-Takagi A (CA), Yagishita S, Nakamura M, Shirai F, Wu Y, Loshbaugh AL, Kuhlman B, Hahn KM, Kasai H.
Labelling and optical erasure of synaptic memory traces in the motor cortex.
Nature 2015; 525, 333-338.

Takahashi N, Sawada W, Noguchi J, Watanabe S, Ucar H, Hayashi-Takagi A, Yagishita S, Ohno M, Tokumaru H, Kasai H.
Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells.
Nat Commun 2015; 6, 8531.

Yagishita S, Hayashi-Takagi A, Ellis-Davies GC, Urakubo H, Ishii S, Kasai H.
A critical time window for dopamine actions on the structural plasticity of dendritic spines.
Science 2014; 345, 1616-1620.

Miyazaki J, Tsurui H, Hayashi-Takagi A, Kasai H, Kobayashi T.
Sub-diffraction resolution pump-probe microscopy with shot-noise limited sensitivity using laser diodes.
Optics Express 2014; 22, 9024-9032.

Hayashi-Takagi A, Araki Y, Nakamura M, (3 authors omitted), Sawa A.
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.
Proc Natl Acad Sci USA 2014; 111, 6461-6466.

Hayashi-Takagi A (CA), Vawter MP, Iwamoto K.
Peripheral Biomarkers Revisited: Integrative Profiling of Peripheral Samples for Psychiatric Research.
Biol Psychiatry 2014; 75, 920-928.

Hayama T, (3 authors omitted), Hayashi-Takagi A, Ellis-Davies GC, Matsuzaki M, Kasai H.
GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.
Nat Neurosci 2013; 16, 1409-1416.

Wei J, Graziane NM, (4 authors omitted), Hayashi-Takagi A ,Korth C, Sawa A, Brandon NJ, Yan Z.
Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1.
Biol Psychiatry 2014; 75, 414-424.

Kato T, Hayashi-Takagi A, Toyota T, Yoshikawa T, Iwamoto K.
Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder.
J Hum Genet 2011; 56, 779-783.

Hayashi-Takagi A, Barker PB, Sawa A.
Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology.
Commun Integr Biol 2011; 4, 211-212.

Wang Q, (12 authors omitted), Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya KI, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, and Brandon NJ.
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Mol Psychiatry 2011; 16, 1006-1023.

Ishizuka K, (10 authors omitted), Hayashi-Takagi A, Okano H, Nakajima K, Houslay MD, Katsanis N, Sawa A.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Nature 2011; 473, 92-96.

Koga M, Serritella AV, Messmer MM, Hayashi-Takagi A, Hester LD, Snyder SH, Sawa A, Sedlak TW.
Glutathione is a physiologic reservoir of neuronal glutamate.
Biochem Biophys Res Commun. 2011; 409, 596-602.

Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Seshadri AJ, Ishizuka K, Makino Y, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, and Sawa A.
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Nat Neurosci 2010; 13, 327-332.

Seshadri S, (4 authors omitted), Hayashi-Takagi A, Ishizuka K, Wong P, Korth C, Anton E, and Sawa A.
Disrupted-in-Schizophrenia-1 expression is regulated by Neuregulin signaling: involvement of Neuregulin, ErbB receptors, Akt, and BACE1.
Proc Natl Acad Sci USA 2010; 107, 5622-5627.

Kasai H, Fukuda M, Watanabe S, Hayashi-Takagi A, Noguchi J.
Structural dynamics of dendritic spines in memory and cognition.
Trends Neurosci 2010; 33, 121-129.

Hayashi-Takagi A (CA), Sawa A.
Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment.
Brain Res Bull 2010; 83, 140-146.

Hayashi A, Kasahara T, Kametani M, Toyota T, Yoshikawa T, Kato T.
Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder.
Int J Neuropsychopharmacol 2009; 1, 33-43.

Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A.
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through Neuregulin-1 and DISC1.
Trends Neurosci 2009; 32, 485-495.

Seshadri AJ, Hayashi-Takagi A (CA).
Gene manipulation with use of stereotaxic viral infection for psychiatric research: spatiotemporal components for schizophrenia.
Prog Brain Res 2009; 179, 17-27.

Yasumoto F, Hayashi A, Kamiya A, Negishi T, Yoshikawa Y, Sawa A.
Genetic manipulation of brain cultures from the primates: a novel tool for molecular studies of neuropsychiatric disorders.
Mol Psychiatry 2008; 13, 116-118.

Hayashi A, Kasahara T, Kametani M, Kato T.
Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1.
Biochem Biophys Res Commun 2008; 376, 758-763.

Sawamura N, (9 authors omitted), Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, and Sawa A.
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Mol Psychiatry 2008; 12, 1138-1148.

Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T.
The role of BDNF-induced XBP1 splicing during brain development.
J Biol Chem 2007; 282, 34525-34.